6-4-Dr. Vladimir Zaichick

Comparison of Twenty Chemical Element Contents in Normal and Goitrous Thyroid

Vladimir Zaichick

Radionuclide Diagnostics Department, Medical Radiological Research Centre, Obninsk, 249036, Russia

*Address for Correspondence:

Prof. Dr. V. Zaichick, Radionuclide Diagnostics Department, Medical Radiological Research Centre, Korolyev St. 4,Obninsk 249036, Russia, Tel: +7 4843960289; Fax: +7 4959561440; E-mail: vzaichick@gmail.com 

Abstract

Background:Nodular goiter (NG) is an internationally important health problem. The aim of this exploratory study was to evaluate whether significantchanges in the thyroid tissue levels of  twenty chemical elements (ChE) Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V, and Zn exist in the goitrous transformed thyroid.

Methods: Thyroid tissue levels of twenty ChEwere prospectively evaluated in 46 patients with NG and 105 healthy inhabitants. Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma atomic emission spectrometry, respectively.  Tissue samples were divided into two portions. One was used for morphological study while the other was intended for ChE analysis.

Results: It was found that contents of Al, B, Br, Cl, Cu, Fe, Li, Mg, Mn, Na, P, S, Si, V, and Zn are significantly higher whereas the levels of I some lowerin NG than in normal tissues.

Conclusion: There are considerable changes in ChE contents in the goitrous tissue of thyroid.

Keywords:Thyroid nodular goiter; Intact thyroid; Chemical elements; Biomarkers for goiter diagnosis; Instrumentalneutron activation analysis; Inductively coupled plasma atomic emission spectrometry.