• Monya Abdullah Yahya El-Zine Departement of Histopathology, Faculty of Medicine and Health Sciences, Sana’a University, Republic of Yemen.
  • Maged Ali Amer Ali Department of Neurosurgery, Faculty of Medicine and Health Sciences, Sana’a University, Republic of Yemen.
  • Hassan Abdulwahab Al-Shamahy Department of Basic Sciences, Faculty of Dentistry, Sana’a University, Republic of Yemen.


Background: Tumors of the central nervous system consist of a heterogeneous grouping of neoplasms of enormous histological variety. In spite of the increasing prevalence of CNS tumors in developing countries, certain places alike Yemen do not have representative studies showing the true impact of these tumors on the population.  

Aims: Description of the distinctiveness of primary and secondary tumors of the CNS in the past ten years in one Yemeni institute. 

Subjects and methods:  A descriptive-observational study was performed on patients with tumors of the CNS who were selectively treated by surgical excision with subsequent diagnosis through a study of pathological tissues at the Saudi German Hospital SGH- Sana'a, over a period of 10 years from January 1, 2009 to December 31, 2019. The variables of the study were qualitative (histological type, gender, affected anatomical position) and quantitative (age). Both group and histopathological diagnoses were formed in line with the 2006 WHO classification of CNS tumors.

Results: There were a total of 359 central nervous system tumors. Of these, 200 were females and 159 were males, with a ratio of 1.3: 1 and a mean age of 49.3 years. The most common tumors were the neuroepithelium (28.4%), meningiomas (26.55%), followed by mesenchymal tumors (13.4%), sellar region tumors (11.14%) and the nerve sheets tumors (11.14%).   Meningiomas had the highest prevalence in female patients (20.33%), while it was in male neuroepithelial tumors (15.32%). Single entity repeat point form, Grade I meningioma was the most common (18.11%) followed by pituitary adenomas (9.2%), Glioblastoma multiform (8.6%), Class II meningiomas (7.24%) and Schwannoma  (6.7%). 

Conclusion:  This is the firstly study of a sequence of cases in Yemen  to be conducted on both benign and malignant tumors of the CNS, with all age groups patients  with a extent of 10 years. Whilst this work represents no more than a retrospective analysis of a single institute, it can be a strong indicator of the epidemiology of the CNS tumors in Yemen.


Peer Review History:

Received 12 March 2021; Revised 26 March; Accepted 22 April, Available online 15 May 2021

Academic Editor: Essam Mohamed Eissaorcid22.jpg, Beni-Suef University, Egypt,

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Received file:blue_23983.gif                Reviewer's Comments:download_logo_r_29189.gif

Average Peer review marks at initial stage: 6.5/10

Average Peer review marks at publication stage: 8.0/10

Reviewer(s) detail:

Dr. George Zhuorcid22.jpg

Tehran University of Medical Sciences, Tehran, Iran,

Dr. Ahmed Mohammed Al-Haddadorcid22.jpg,

Hadhramout University, Al-Mukalla, Yemen,

Keywords: Central nervous system tumors, Histology, Pathology, Prevalence, Yemen


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How to Cite
El-Zine, M. A. Y., M. A. A. Ali, and H. A. Al-Shamahy. “PREVALENCE OF CNS TUMORS AND HISTOLOGICAL RECOGNITION IN THE OPERATED PATIENTS: 10 YEARS EXPERIENCE IN YEMEN”. Universal Journal of Pharmaceutical Research, Vol. 6, no. 2, May 2021, doi:
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