IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE
Objective: Diarrhoeal disease is responsible for mortality and morbidity, especially among children in developing countries causing a major healthcare problem. The purpose of the present study was to evaluate anti-diarrhoeal effects of methanolic extract of whole plant of Bombax buonopozense against castor oil-induced-diarrhoea model and small intestine transit model in rats.
Methods: Albino wistar rats were used for estimation of anti-diarrhoeal activity. Small intestinal transit models in rats the number of droppings and the distance traveled by charcoal in intestine were measured. Loperamide (2.5 mg/kg) was used as standard drug, and it has shown significant reductions in fecal output and frequency of droppings whereas extract at the doses of 200 and 400 mg/kg reduced the castor-oil induced frequency and consistency of diarrhoea.
Results: The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrhoeal agent.
Conclusion: Results conclude that the leaves extract of Bombax buonopozense contains bioactive natural substances with antidiarrhoeal properties.
Peer Review History:
Received 8 February 2017; Revised 25 February; Accepted 28 February, Available online 15 March 2017
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Average Peer review marks at initial stage: 3.5/10
Average Peer review marks at publication stage: 7.0/10