IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE

  • Fatima A. Adamude Department of Biochemistry Federal University Lafia, Nigeria
  • Moh Kingsley Onyekachi Department of Biological Sciences, Ahmadu Bello University Zaria, Nigeria

Abstract

Objective: Diarrhoeal disease is responsible for mortality and morbidity, especially among children in developing countries causing a major healthcare problem. The purpose of the present study was to evaluate anti-diarrhoeal effects of methanolic extract of whole plant of Bombax buonopozense against castor oil-induced-diarrhoea model and small intestine transit model in rats. 


Methods: Albino wistar rats were used for estimation of anti-diarrhoeal activity. Small intestinal transit models in rats the number of droppings and the distance traveled by charcoal in intestine were measured.  Loperamide (2.5 mg/kg) was used as standard drug, and it has shown significant reductions in fecal output and frequency of droppings whereas extract at the doses of 200 and 400 mg/kg reduced the castor-oil induced frequency and consistency of diarrhoea. 


Results: The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrhoeal agent.


Conclusion: Results conclude that the leaves extract of Bombax buonopozense contains bioactive natural substances with antidiarrhoeal properties.


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Peer Review History:


Received 8 February 2017;   Revised 25 February; Accepted 28 February, Available online 15 March 2017


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Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 3.5/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Dr. Gülay B Anadoluorcid22.jpg, Anadolu University, Eskisehir, Turkey, gbuyukko@anadolu.edu.tr


 Prof. Dr. Hüsniye Kayalarorcid22.jpg, Ege University, Turkey, husniyekayalar@gmail.com


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Keywords: Antidiarrhoeal activity, Bombax buonopozense, castor oil induced diarrhoea, small intestinal transit, charcoal

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How to Cite
Adamude, F., and M. Onyekachi. “IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 1, Jan. 2017, doi:https://doi.org/10.22270/ujpr.v2i1.R1.
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Research Articles