FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE

  • Sonia Paliwal Department of pharmaceutics, Global Institute of pharmaceutical education and research, Kashipur, Uttrakhand, India
  • Gurleen Kaur Department of pharmaceutics, Global Institute of pharmaceutical education and research, Kashipur, Uttrakhand, India
  • Rajeshwar KK Arya Department of pharmaceutical Sciences, Kumaon University, Bhimatal, Nainital, Uttrakhand, India.

Abstract

Objective:  Terbinafine is a broad spectrum antifungal drug. The aim of present study was to develop topical nano emulgel of terbinafine using carbopol 934 as a gelling agent. The objective behind the formulation was to avoid dosing frequency and to increase the stability and bioavailability by avoiding the first pass metabolism.


Methods: The formulations were prepared by using oleic acid, carbopol 934, span 20, propylene glycol in different ratios and analyzed by pseudo tertiary phase diagram. All the five prepared nano emulgel formulations have shown satisfactory physiochemical properties. The stability and particle size is been determined by zeta potential.


Results: The highest drug release 82.38 %was found in formulations of batch F4, which follows non-fickian mechanism. The studies showed that changing the concentration of oil, surfactant, co surfactant and double distilled water as aqueous phase has an impact on the behavior and thermodynamic stability of the nanoemulsion.


Conclusion: Study concludes that of Terbinafine can be delivered effectively by nano emulgel  formulations.


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Peer Review History:


Received 28 November 2018;   Revised 11 December; Accepted 25 December, Available online 15 January 2019


Academic Editor: Dr. Jennifer Audu-Peterorcid22.jpg, University of Jos, Nigeria, drambia44@gmail.com


UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.


Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 8.5/10


Reviewer(s) detail:


Dr. Mohamed Salamaorcid22.jpg, Modern University for Technology & Information, Egypt, salama47@yahoo.com


Dr. Mahmoud S. Abdallahorcid22.jpg, University of Sadat city, Egypt, dr_samy777@yahoo.com


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Keywords: Antifungal drug, nano emulsion, nano emulgel, Terbinafine, topical drug delivery, tertiary phase

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Paliwal, S., G. Kaur, and R. K. Arya. “FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 6, Jan. 2019, doi:https://doi.org/10.22270/ujpr.v3i6.223.
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Research Articles