BIODEGRADATION OF PARACETAMOL BY NATIVE FUNGAL SPECIES INHABITING WASTEWATER OF A PHARMACEUTICAL FACTORY IN SANA’A, YEMEN

  • Wadhah Hassan Edrees Microbiology Division, Biology Department, Faculty of Science, Sana’a University
  • Qais Yusuf Abdullah Microbiology Division, Biology Department, Faculty of Science, Sana’a University
  • Khalid Mohamed Naji Chemistry Department, Faculty of Science, Sana’a University, Yemen
  • Ali Gamal AL-Kaf Medicinal Chemistry Department, Faculty of Pharmacy, Sana’a University.
10.22270/ujpr.v2i6.R7

Keywords:

Lozenges, HPMC K4M, Carbamazepine (CBZ), swallowing, in vitro dissolution, stability studies

Abstract

Objectives: Paracetamol has emerged as an important environmental contaminant due to its extensive use. The purpose of this work was toisolate, identify, and characterize fungal species able to degrade paracetamol from pharmaceutical wastewater effluent at Sana'a City, Yemen.

Methods: The fungi were isolated and purified from wastewater samples using enrichment and selective media. The isolated fungi were identified according to phenotypic characterization. Two species of isolated fungi were able to utilize the paracetamol as the sole of carbon and energy sources. These fungi were designated as F1 and F2 and identified as Aspergillus niger and Fusarium oxysporium, respectively. Optimum temperature and pH for growth of both species were 25˚C and 6.0, respectively. Also, the biodegradation of paracetamol was influenced by glucose concentration.

Results:  F1 and F2 were able to degrade 35.7% and 26.1% of 1000 and 2000 mg/l, respectively, paracetamol in 60 days. This is the first report on the ability of Aspergillus niger and Fusarium oxysporium to degrade paracetamol.

Conclusion:  The reported findings highlight the potential use of the isolated microorganisms for treatment of paracetamol-contaminated wastewater.

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Peer Review History:

Received 5 October 2017;   Revised 10 November; Accepted 22 December, Available online 15 January 2018

Academic Editor: Dr. Ali Abdullah Al-yahawiorcid22.jpg, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com

Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif

Average Peer review marks at initial stage: 5.5/10

Average Peer review marks at publication stage: 7.5/10

Reviewer(s) detail:

Dr. Fátima Morales Marínorcid22.jpg, University of Murcia, Spain, fatima.morales@um.es

Dr. Naglaa Mohamed Ahmed Abd Elaalorcid22.jpg, Helwan University, Egypt, nogamoon2005@yahoo.com

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Published

2017-11-01

How to Cite

Edrees, W. H., Q. Y. Abdullah, K. M. Naji, and A. G. AL-Kaf. “BIODEGRADATION OF PARACETAMOL BY NATIVE FUNGAL SPECIES INHABITING WASTEWATER OF A PHARMACEUTICAL FACTORY IN SANA’A, YEMEN”. Universal Journal of Pharmaceutical Research, vol. 2, no. 6, Nov. 2017, doi:10.22270/ujpr.v2i6.R7.

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