EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA
Objectives: The objective of present investigation was to isolate an effective novel mucoadhesive biomaterial from the pulp of Achras zapotilla, belonging to Sapotaceae family. In the recent years the research in the biomaterial isolation and their use as pharmaceutical excipients become a core area for formulation scientist to develop safe and effective drug delivery system.
Methods: The biomaterial was isolated by simplified economical method and was subjected to phytochemical, physicochemical, micromeritic as well as spectral analyses like IR, 1HNMR, DSC, SEM and Elemental analysis. The mucoadhesive property of the biomaterial was assessed by shear stress method, falling sphere method and rotating cylinder method using nasal mucosa as substrates.
Results: The results were compared with HPMC and sodium CMC as a standard. The formation of hydrogen bond by natural mucoadhesive agent with mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups.
Conclusion: The research study revealed that the biomaterial obtained from fruit pulp of Acarus zapotila exhibited a promising potent natural mucoadhesive property and may be used to develop mucoadhesive transmucosal drug delivery systems.
Peer Review History:
Received 4 December 2018; Revised 8 January; Accepted 12 January, Available online 15 January 2018
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Average Peer review marks at initial stage: 4.5/10
Average Peer review marks at publication stage: 7.0/10