DR. MOHAMED ISMAIL NOUNOU

Biography

Dr. Mohamed Ismail Nounou is working as an Assistant Professor in Department of Pharmaceutical Sciences, Appalachian College of Pharmacy, Oakwood, VA 24631, USA.

Research Area

He has more than 17 yrs of  research and teaching experience. His field of specialization is pharmaceutics.

  • Extensive experience in various biochemical and molecular biology techniques including immunohistochemistry (IHC),
    immunofluorescence, protein and peptide labeling, gene expression, Western Blot (WB), DNA / RNA preparation, gel
    electrophoresis, cell culture and flow cytometry.
  • Technical experience with histologic processing of tissues, cryopreservation & sectioning and working with mammalian,
    cancer and stem cell lines.
  • Extensive experience with numerous imaging techniques including light, fluorescence, confocal, multiphoton, scanning
    electron and transmission electron microscopes using different software packages such as 3i SlideBook and others.
    Extensive experience with chemotherapy distribution in brain metastases of breast cancer.
  • Extensive experience in mouse models to study the brain tumors and metastases and myocardial infarction at the cellular
    and functional levels.
  • Strong grasp of the design and the characterization of specially tailored polymers for gene and drug delivery.
    Development of genetically modified animal models for brain metastases.
  • Knowledgeable about developing targeting moieties-drug bioconjugates and applying appropriate biophysical and
    biochemical characterization methods of protein-drug conjugates.
  • Knowledgeable about physico-chemical characterization of cationic polymer (polyplexes) delivery vehicles, along with their
    evaluation 
    in-vitro and in-vivo.
  • Well-versed in the design, the characterization and the in-vitro/in-vivo evaluation of polymeric and vesicular delivery
    systems such as stealth liposomes, ultradeformable vesicles, ethosomes, microspheres and nanoparticles.
  • Extensive experience with polymer, lipids and dosage forms stability testing.
    Adept at developing topical formulations combined with in-depth knowledge of delivery vehicles based on liposomes,
    micelles and polymeric/protein particles for water insoluble drugs.
  • Proficient at controlling release from semi-solid and suspension formulations and polymeric-drug matrices.
  • Experience with various models of in-vitro drug release from different formulations and dosage forms.
  • Extensive experience with establishing genetically modified stable cell lines to be used for in-vitro and in-vivo evaluation
    of drug and gene delivery systems.
  • Experienced in physico-chemical properties of drugs and their interactions with formulation excipients.
  • Solid knowledge of techniques and methods development for quantitative characterization of drugs, including peptide/
    proteins interactions with cells, along with their the sub-cellular trafficking.
  • Adept at evaluating anti-proliferative and cytotoxic activity of anti-cancer agents.
  • Demonstrated strong leadership skills in managing research for drug formulation development.
  • Experience with analytical techniques such as 1H and 13C NMR, IR, column chromatography, HPLC and MALDI-TOF.
  • Broad scope of knowledge of HPLC spectroscopy, GPC, UV and fluorescence spectroscopy, near infra-red spectroscopy, flow  cytometry and immunoassays.
  • Extensive experience with radio labeling and radiopharmaceuticals handling and analysis.
  • Strong grasp of the design, synthesis and the characterization of specially tailored polymers and peptidomemetic structures
    for gene and drug delivery.

E-mail

nounou@acp.edu