@article{Adegbenro_Opeyemi_2019, title={DEVELOPMENT AND ESTIMATION OF ANTI-INFLAMMATORY ACTIVITY OF TOPICAL ETORICOXIB EMULGEL BY CARRAGEENAN INDUCED PAW OEDEMA METHOD}, volume={4}, url={https://www.ujpr.org/index.php/journal/article/view/265}, DOI={10.22270/ujpr.v4i3.265}, abstractNote={<p><strong>Objective:</strong> Emulgel is one of the emerging topical drug delivery system for the delivery of hydrophobic drugs which overcome various disadvantages of ointments and creams such as greasiness and phase inversion. Etoricoxib is poorly aqueous soluble Non steroidal Anti-Inflammatory Drug (NSAID). It is used in osteoarthritis, rheumatoid arthritis, acute gouty arthritis, ankylosing spondylitis, low back pain, acute postoperative pain, and primary dysmenorrheal. Its oral delivery is associated with greater chance of adverse effects or therapeutic failure and large amount of drug is lost in the vicinity of the target organ. Also oral administration of etoricoxib causes gastro-intestinal irritation. The aim of the present study was to develop an emulgel formulations using the gelling agent like Carbopol 934 and HPMC K4M with emulsifiers like Span 20 and Tween 20. <br /><strong>Methods:</strong> Six emulgel formulations were developed and evaluated on different parameters like physical appearance, pH, viscosity, extrudability, drug content, spreadability, in-vitro diffusion studies, and skin irritation test. <br /><strong>Results:</strong> All trials of emulgel were found to be homogeneous and smears were transparent without grittiness or presence of any particles. The pH values of emulgel batches were found in the range of 6.8-7.1 which is similar to skin pH.<br /><strong>Conclusion:</strong> Best formulation of batch EG1 was further evaluated for stability study and anti-inflammatory activity in carrageenan induced rat paw edema. Anti-inflammatory effect of formulation EG1 was compared with standard market product Indomethacin.</p> <p>                         <img src="https://ujpr.org/public/site/images/drkkc/R51.gif" /></p> <p><a href="https://scholar.google.co.in/scholar?oi=bibs&hl=en&cites=13563073691451329796" target="_blank" rel="noopener"><img src="https://ujpr.org/public/site/images/jmanager/Google_scholar_image9.JPG" /></a></p> <p><strong>Peer Review History: </strong></p> <p><strong>Received </strong>1 May 2019;<strong>   Revised </strong>12 June;<strong> Accepted </strong>4 July,<strong> Available online </strong>15 July 2019</p> <p style="text-align: justify;"><strong>Academic Editor: </strong><strong>Dr. Ali Abdullah Al-yahawi<sub><a href="https://orcid.org/0000-0002-1099-7778" target="_blank" rel="noopener"><img src="https://ujpr.org/public/site/images/editor/orcid22.jpg" /></a></sub></strong>, Al-Razi university, Department of Pharmacy, Yemen, <em>alyahawipharm@yahoo.com</em></p> <p><strong>Received file:<a href="http://ujpr.org/2019/4-3-r5.pdf" target="_blank" rel="noopener"><img src="https://ujpr.org/public/site/images/drkk/blue_23983.gif" /></a>                Reviewer’s Comments:<a href="http://ujpr.org/2019/4-3-r5-comments.docx" target="_blank" rel="noopener"><img src="https://ujpr.org/public/site/images/drkk/download_logo_r_29189.gif" /></a></strong></p> <p><strong>Average Peer review marks at initial stage:</strong> 5.5/10</p> <p><strong>Average Peer review marks at publication stage:</strong> 8.5/10</p> <p><strong>Reviewer(s) detail:</strong></p> <p><strong>Dr. Sally A. El-Zahaby<sub><a href="https://orcid.org/0000-0002-8751-990X" target="_blank" rel="noopener"><img src="https://ujpr.org/public/site/images/editor/orcid22.jpg" /></a></sub></strong>, Pharos University in Alexandria, Egypt, <em>sally.elzahaby@yahoo.com</em></p> <p><strong>Dr. Evren Alğin Yapar<sub><a href="https://orcid.org/0000-0002-6504-4608" target="_blank" rel="noopener"><img src="https://ujpr.org/public/site/images/editor/orcid22.jpg" /></a></sub></strong>, Turkish Medicines and Medical Devices Agency, Turkiye, <em>evren.yapar@yahoo.com</em></p> <p><strong>Similar Articles:</strong></p> <p><a href="http://ujpr.org/index.php/journal/article/view/223" target="_blank" rel="noopener">FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE</a></p>}, number={3}, journal={Universal Journal of Pharmaceutical Research}, author={Adegbenro, Obanewa Opeyemi and Opeyemi, Oyeniran Taiwo}, year={2019}, month={Jul.} }