@article{Singh_Singh_Madhv_2017, title={EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA}, volume={2}, url={https://www.ujpr.org/index.php/journal/article/view/102}, DOI={10.22270/ujpr.v2i6.R6}, abstractNote={<p><strong>Objectives: </strong>The objective of present investigation was to isolate an effective novel mucoadhesive biomaterial from the pulp of <em>Achras zapotilla</em>, belonging to Sapotaceae family. In the recent years the research in the biomaterial isolation and their use as pharmaceutical excipients become a core area for formulation scientist to develop safe and effective drug delivery system.</p> <p><strong>Methods: </strong>The biomaterial was isolated by simplified economical method and was subjected to phytochemical, physicochemical, micromeritic as well as spectral analyses like IR, 1HNMR, DSC, SEM and Elemental analysis. The mucoadhesive property of the biomaterial was assessed by shear stress method, falling sphere method and rotating cylinder method using nasal mucosa as substrates.</p> <p><strong>Results:</strong>  The results were compared with HPMC and sodium CMC as a standard. The formation of hydrogen bond by natural mucoadhesive agent with mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups.</p> <p><strong>Conclusion:</strong><strong>  </strong>The research study revealed that the biomaterial obtained from fruit pulp of<em> Acarus zapotila </em>exhibited a promising potent natural mucoadhesive property and may be used to develop mucoadhesive transmucosal drug delivery systems.</p> <p>              <img src="https://www.ujpr.org/public/site/images/editor/69.JPG" /></p> <p><strong>Peer Review History: </strong></p> <p><strong>Received</strong> 5 October 2017;   <strong>Revised</strong> 14 November; <strong>Accepted</strong> 28 December, <strong>Available online</strong> 15 January 2018</p> <p style="text-align: justify;"><strong>Academic Editor:  </strong></p> <p style="text-align: justify;"><strong>Dr. A.A. Mgbahurike<sub><a href="https://orcid.org/0000-0002-4355-7250" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/editor/orcid22.jpg" /></a></sub></strong>, University of Port Harcourt, Nigeria, <em>amaka_mgbahurike@yahoo.com</em></p> <p><strong>Received file:<a href="http://ujpr.org/2017/2-6-r6.pdf" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/drkk/blue_23983.gif" /></a>        Reviewer’s Comments:<a href="http://ujpr.org/2017/2-6-r6-comments.docx" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/drkk/download_logo_r_29189.gif" /></a></strong></p> <p><strong>Average Peer review marks at initial stage:</strong> 4.5/10</p> <p><strong>Average Peer review marks at publication stage:</strong> 7.0/10</p> <p><strong>Reviewer(s) detail:</strong></p> <p><strong>Dr. </strong><strong>Areen Alshweiat<a href="https://orcid.org/0000-0001-7008-0972" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/editor/orcid22.jpg" /></a></strong>, University of Szeged, Hungary, <em>areen.alshweiat@hu.edu.jo</em></p> <p><strong>Dr. Emmanuel O. Olorunsola<sub><a href="https://orcid.org/0000-0002-6041-2563" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/editor/orcid22.jpg" /></a></sub></strong>, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, <em>olorunsolaeo@yahoo.com</em></p> <p><strong>Similar Articles:</strong></p> <p><a href="http://ujpr.org/index.php/journal/article/view/23" target="_blank" rel="noopener">ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION </a></p>}, number={6}, journal={Universal Journal of Pharmaceutical Research}, author={Singh, Arun Kumar and Singh, Anita and Madhv, N.V Satheesh}, year={2017}, month={Nov.} }