EFFECT AND MECHANISM OF TRADITIONAL CHINESE MEDICINE HUOLOU GUKANG PILL COMBINED WITH SIMVASTATIN ON STEROID-INDUCED NECROSIS OF FEMORAL HEAD

  • Qingfan Han Department of Orthopedics,Affiliated Hospital of Qiingdao University Qingdao, Shandong, PR China 266000
  • Dezhi Wang Department of Orthopedics,Affiliated Hospital of Qiingdao University Qingdao, Shandong, PR China 266000 https://orcid.org/0000-0002-3427-8866

Abstract

Aim of present study was to explore the effect and mechanism of traditional Chinese medicine HuoLou Gukang pill combined with simvastatin on steroid-induced necrosis of femoral head. A total of 130 patients with steroid-induced necrosis of femoral head treated in our hospital from January 2016 to April 2017 were randomly divided into control group and study group. Each group had 65 cases. Control group were treated with simvastatin, patients in study group were treated with traditional Chinese medicine HuoLuo GuKang pill on the basis of control group. Before and after treatment, patients were tested for adiponectin, TNF-α, blood lipid and blood glucose. Harris score and VAS score were also measured. There was no significant difference in adiponectin, TNF-α, blood glucose, CH, TG, HDL-C and LDL-C between two groups before treatment (P>0.05). After treatment, the levels of adiponectin and HDL-C in study group were significantly higher than those in control group (P<0.05), but the levels of TNF-a, blood glucose, CH, TG and LDL-C in study group were significantly lower than those in control group (P<0.05). There was no significant difference in Harris score and VAS score between two groups before treatment (P>0.05). The Harris score of study group was significantly higher than that of control group after treatment (P<0.05). The VAS score of study group was significantly lower than that of control group (P<0.05). After follow-up comparative analysis, there was no significant difference between Harris score and VAS score in study group (P>0.05), but there was significant difference in control group (P<0.05). The efficacy of two groups was analyzed based on Harris scores: The total effective rate was 96.9% in study group and 86.2% in control group (P<0.05). The efficacy of two groups was analyzed based on VAS scores: The total effective rate of study group was 95.4%, significantly higher than that of control group (84.6%), and the difference was statistically significant (P<0.05).The treatment effect of Chinese medicine HuoLou Gukang pill combined with simvastatin on steroid-induced necrosis of femoral head is better than that of simvastatin. Chinese medicine HuoLou Gukang pills combined with simvastatin can intervene the development of steroid-induced necrosis of femoral head effectively, prevent malignant progress and reduce incidence of patients by reducing blood lipid and improving hemodynamic mechanism, thus it is worthy being popularized and applied.


Peer Review History:


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Received file


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Average Peer review marks at initial stage: 6.5/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Dr. Sabah Hussien El-Ghaiesh


Affiliation: Tanta University, Egypt


E-mail: s.ghaiesh@gmail.com


 


Name: Dr. Francis Adou Yapo


Affiliation: University of Abidjan, Ivory Coast


E-mail: fyapo@yahoo.fr


Comments of reviewer(s):


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Keywords: Simvastatin, HuoLou Gukang pills, steroid-induced necrosis of femoral head, treatment, mechanism
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How to Cite
Han, Q., and D. Wang. “EFFECT AND MECHANISM OF TRADITIONAL CHINESE MEDICINE HUOLOU GUKANG PILL COMBINED WITH SIMVASTATIN ON STEROID-INDUCED NECROSIS OF FEMORAL HEAD”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 6, Nov. 2017, doi:https://doi.org/10.22270/ujpr.v2i6.R3.
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Research Articles