PREPARATION AND CHARACTERIZATION OF THYMOQUINONE NANOPARTICLES PEGYLATED AS DRUG DELIVERY SYSTEM

  • A. Hasrawati Pharmaceutical Department, Faculty of Pharmacy, Universitas Muslim, Indonesia.
  • Irsan Rizaldi Faculty of Pharmacy, Universitas Muslim, Indonesia.
  • Deisy Febrianti Faculty of Pharmacy, Universitas Muslim, Indonesia.
  • A Mumtihanah Mursyid Pharmaceutical Department, Faculty of Pharmacy, Universitas Muslim, Indonesia.
  • Neneng Amelia Bakri Pharmaceutical Department, Faculty of Pharmacy, Universitas Muslim, Indonesia.

Abstract

Objective: Thymoquinone is a main component of Black Cumin (Nigella  sativa Linn.) with various pharmacological activities, but has poor stability and bioavailability. The purpose of this study was to carry out the preparation and characterization of timoquinone nanoparticles PEGylation.


Methods: The Thymoquinone nanoparticles  (TQ-NP) were made with PEGylation using PEG 6000 with the concentrations on each preparation of 3 mM (A), 4 mM (B), and 5 mM (C) then were evaluated by the parameter of yield percentage Entrapment Efficiency (EE) and Drug Loading (DL), drug release, size and distribution particle, morphological analysis and Fourier Transform-Infrared spectrophotometer (FTIR).


Results: Thymoquinone nanoparticle was PEGylated with PEG 6000  has the highest efficiency entrapment of 99.9718±0.029% in formula A, with the capacity of drug loading 0,66%. Formulation A release 99.9718±0.029% of Thymoquinone at 50 minutes. The morphological observations with Scanning Electron Microscope (SEM) showed spherical nanoparticles morphology.


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Peer Review History:


Received 11 September  2020; Revised 5 Decembe; Accepted 3 January, Available online 15 January 2021


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Received file:blue_23983.gif                Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 6.0/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Dr. Evren Alğin Yaparorcid22.jpg, Turkish Medicines and Medical Devices Agency, Turkiye, evren.yapar@yahoo.com


Dr. Sally A. El-Zahabyorcid22.jpg, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com


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Keywords: Black Cumin, Nanoparticles, PEG 6000, Pegylation, Thymoquinone

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How to Cite
Hasrawati, A., I. Rizaldi, D. Febrianti, A. M. Mursyid, and N. A. Bakri. “PREPARATION AND CHARACTERIZATION OF THYMOQUINONE NANOPARTICLES PEGYLATED AS DRUG DELIVERY SYSTEM”. Universal Journal of Pharmaceutical Research, Vol. 5, no. 6, Jan. 2021, doi:https://doi.org/10.22270/ujpr.v5i6.506.
Section
Research Articles