FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS CONTAINING EXTRACT OF SOLENOSTEMMA ARGEL (HARGEL)
Objective: The objective of the present study is to formulate colon targeted matrix tablets containing Solenostemma argel extract using guar gum alone or in combination with either HPMC K15M, with Eudragit S100, or with both them.
Methods: The Hargel colon targeted matrix tablets were prepared by wet granulation method. The prepared matrix tablets were evaluated for the weight variation, hardness, friability, and in-vitro drug release study in three different media. The formulations showed compliance with pharmacopoeial standards except that containing guar gum alone.
Results: There was no interaction between drug, polymer and other excipients. It was confirmed by FTIR studies. Among the formulations, GHE2 (i.e. containing triple polymer mixture) showed good results in release retardation and other physicochemical properties of matrix tablets when compare to other formulations.
Conclusion: The optimum formulation (GHE2) was stable when it was stored at 450/75% RH for 3 months. The formulation GHE2 was considered the most suitable formula for targeted the colon.
Peer Review History:
Received 30 July 2019; Revised 9 August; Accepted 3 September, Available online 15 September 2019
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Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 9.0/10
Name: Areen Alshweiat
Affiliation: University of Szeged, Hungary
Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab
Affiliation: Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia
Comments of reviewer(s):