FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS CONTAINING EXTRACT OF SOLENOSTEMMA ARGEL (HARGEL)

  • Abdullah Hameed Maad Department of Pharmaceutics, Khartoum University, P.O. Box 1996, Sudan.
  • Mohammed El-Hassan Ali Shayoub Department of Pharmaceutics, Khartoum University, P.O. Box 1996, Sudan.
  • Elamin Ibrahim Elnima Department of Pharmaceutics, Khartoum University, P.O. Box 1996, Sudan.
  • Zuheir Osman Department of Pharmaceutics, Khartoum University, P.O. Box 1996, Sudan.
  • Fatehalrahman F. Magbool Department of Pharmaceutics, Khartoum University, P.O. Box 1996, Sudan.

Abstract

The objective of the present study is to formulate colon targeted matrix tablets containing Solenostemma argel extract using guar gum alone or in combination with either HPMC K15M, with Eudragit S100, or with both them. The Hargel colon targeted matrix tablets were prepared by wet granulation method. The prepared matrix tablets were evaluated for the weight variation, hardness, friability, and in-vitro drug release study in three different media. The formulations showed compliance with pharmacopial standards except that containing guar gum alone. There was no interaction between drug, polymer and other excipients. It was confirmed by FTIR studies. Among the formulations, GHE2 (i.e. containing triple polymer mixture) showed good results in release retardation and other physicochemical properties of matrix tablets when compare to other formulations. The optimum formulation (GHE2) was stable when it was stored at 450/75% RH for 3 months. The formulation GHE2 was considered the most suitable formula for targeted the colon.


Peer Review History:


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Received file


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Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 9.0/10


Reviewer(s) detail:


Name: Areen Alshweiat


Affiliation: University of Szeged, Hungary


E-mail: areen.alshweiat@hu.edu.jo


 


Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab


Affiliation: Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia


E-mail: mohawahab2002@yahoo.com


Comments of reviewer(s):


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Keywords: Colon Targeted Matrix Tablets, Eudragit S100, Guar Gum, HPMC K15M, Hargel Extract
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How to Cite
Maad, A. H., M. E.-H. Ali Shayoub, E. I. Elnima, Z. Osman, and F. F. Magbool. “FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS CONTAINING EXTRACT OF SOLENOSTEMMA ARGEL (HARGEL)”. Universal Journal of Pharmaceutical Research, Vol. 4, no. 4, Sept. 2019, doi:https://doi.org/10.22270/ujpr.v4i4.297.
Section
Research Articles