PREVALENCE OF DYSLIPIDEMIA AND ITS ASSOCIATION WITH DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SULAIMANI GOVERNORATE

  • Soran Mohammed Gharib Ministry of Higher education and Scientific researched KRG, Ministry of Health KRG, Sulaimani City, Iraq-Kurdistan.

Abstract

Rheumatoid arthritis is a systemic inflammatory disease characterized by  chronic and erosive polyarthritis it is  the most common inflammatory arthritis, affecting from 0.5-1% of the general population. Dyslipidemia is a quite important problem in Rheumatoid arthritis (RA) patient, which causes morbidity and mortality. As known, dyslipidemia is one of atherosclerosis risk-factor, and main mortality cause of longstanding RA patient. Objectives are to measure Prevalence of dyslipidemia in patients with Rheumatoid Arthritis compared with healthy control peoples and to find out correlations between dyslipidemia and disease activity in patients with Rheumatoid Arthritis. A total of one hundred patients with RA (80 female and 20 male) were included in the study, they were attending consultation  clinic and division of Rheumatology in the General Medical Teaching Hospital in Slemani city from (October 2015 to September 2016)  who fulfilling the 2010 American College of  Rheumatology/European league against Rheumatism classification criteria for RA and one hundred healthy  age and  sex-matched controls. Fasting lipid profiles of cases and control were estimated after an overnight fast of 12 hours. Association between lipid profile and disease activity using disease activity score DAS 28, inflammatory markers (CRP and ESR) was also determined.  RA patients showed a higher prevalence of associated dyslipidemia (48%) in comparison to control (4%) p- value less than 0.001.Our result showed a significant reduction in serum high density lipoproteins (HDL) p-value less than 0.001, with significant elevation of serum total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein p-value 0.001, 0.007, 0.01and 0.5  respectively in comparison to controls. There is a significant association between dyslipidemia and high DAS 28 score (p=0.02). There is  a significant association between high ESR of RA patients and dyslipidemia (p=0.001). A significant association was observed between high CRP level and RA patients with no dyslipidemia (p<0.001). Dyslipidemia are frequent among the patients with rheumatoid arthritis and highly associated with active RA. Serum HDL significantly reduced while other parameters of lipid profiles significantly increased in comparisons to control.


Google Scholar


Peer Review History:


UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.


Received file


pdf3.JPG


Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Name: Dr. Ahmad Abdelsattar El-Ebiary


Affiliation: Tanta University Hospitals, Tanta, Egypt


E-mail: a.ebiary@med.tanta.edu.eg


Comments of reviewer(s):


pdf3.JPG

Keywords: Rheumatoid arthritis, dyslipidemia, disease activity
Statistics
68 Views | 95 Downloads
How to Cite
Gharib, S. “PREVALENCE OF DYSLIPIDEMIA AND ITS ASSOCIATION WITH DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SULAIMANI GOVERNORATE”. Universal Journal of Pharmaceutical Research, Vol. 1, no. 2, Nov. 2016, doi:https://doi.org/10.22270/ujpr.v1i2.R4.
Section
Research Articles