FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE

Sonia Paliwal; Gurleen Kaur; Rajeshwar KK Arya

doi:10.22270/ujpr.v3i6.223

Sonia Paliwal Department of pharmaceutics, Global Institute of pharmaceutical education and research, Kashipur, Uttrakhand, India
Gurleen Kaur Department of pharmaceutics, Global Institute of pharmaceutical education and research, Kashipur, Uttrakhand, India
Rajeshwar KK Arya Department of pharmaceutical Sciences, Kumaon University, Bhimatal, Nainital, Uttrakhand, India.

10.22270/ujpr.v3i6.223

Keywords:

Antifungal drug, nano emulsion, nano emulgel, Terbinafine, topical drug delivery, tertiary phase

Abstract

Objective: Terbinafine is a broad spectrum antifungal drug. The aim of present study was to develop topical nano emulgel of terbinafine using carbopol 934 as a gelling agent. The objective behind the formulation was to avoid dosing frequency and to increase the stability and bioavailability by avoiding the first pass metabolism.

Methods: The formulations were prepared by using oleic acid, carbopol 934, span 20, propylene glycol in different ratios and analyzed by pseudo tertiary phase diagram. All the five prepared nano emulgel formulations have shown satisfactory physiochemical properties. The stability and particle size is been determined by zeta potential.

Results: The highest drug release 82.38 %was found in formulations of batch F4, which follows non-fickian mechanism. The studies showed that changing the concentration of oil, surfactant, co surfactant and double distilled water as aqueous phase has an impact on the behavior and thermodynamic stability of the nanoemulsion.

Conclusion: Study concludes that of Terbinafine can be delivered effectively by nano emulgel formulations.