EpCAM is a cell adhesion molecule. Its structure, its expression and the oncogenic potential, and its signaling network and target therapy were in concise reviewed. In recent advances, in addition to PI3K/akt and Raf/MAPK pathway involving in cell survival, anti-apoptosis and proliferation,and malignant initiation and progression, three distinct pathway are illustrated: EpCAM/E-cadherin-catenin-actin cytoskeleton, EpCAM/wint-catenin signaling and its major EpCAM/nuclear signaling presented by Maetzel D in 2009 and Munz M in 2004. Moreover, more accumulated data are needed in detail mechanism. The data may provide its cancer biology and clinical targeting therapy benefits.


Peer Review History:

Received 28 February 2018;   Revised 25 April; Accepted 10 May, Available online 15 May 2018

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Received file


Average Peer review marks at initial stage: 4.5/10

Average Peer review marks at publication stage: 7.5/10

Reviewer(s) detail:

Name: Fatehalrahman F. Magbool

Affiliation: University of Khartoum, Sudan

E-mail: fmagbool@yahoo.com

Comments of reviewer(s):


Keywords: EpCAM, nuclear signaling, structure, target therapy

Author Biography

George Zhu, Institute of Oncology, Tehran University of Medical Sciences, Tehran, Iran.



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How to Cite
Zhu, G. “EpCAM- AN OLD CANCER ANTIGEN, TURNED ONCOGENIC RECEPTOR AND ITS TARGETING IMMUNOTHERAPY”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 2, May 2018, pp. 43-48, doi:https://doi.org/10.22270/ujpr.v3i2.140.
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