ANTIFUNGAL, CYTOTOXIC AND PHYTOTOXICITY OF AERIAL PART OF RANUNCULUS MURICATUS

  • Muhammad Shahzad Aslam School of Bioprocess Engineering, University Malaysia Perlis, Kompleks Pusat Pengajian, Jejawi 3, 02600 Arau, Perlis, Malaysia.
  • Rubina Rehman Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Bashir A. Choudhary Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Abdul Subhan Ijaz Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Muhammad Uzair School of Bioprocess Engineering, University Malaysia Perlis, Kompleks Pusat Pengajian, Jejawi 3, 02600 Arau, Perlis, Malaysia.
  • Muhammad Syarhabil Ahmad School of Bioprocess Engineering, University Malaysia Perlis, Kompleks Pusat Pengajian, Jejawi 3, 02600 Arau, Perlis, Malaysia.

Abstract

Objectives: The present research is preliminary biological screening of aerial plant of Ranunculus muricatus (Ranunculaceae). Dichloromethane and methanol extracts of the aerial plant were investigated for their antifungal, phytotoxic and cytotoxic activities.  


Methods: Anti-fungal, cytotoxicity and phytotoxicity activities were performed by agar tube dilution assay, brine shrimp lethality bioassay and lemna bioassay respectively. Dichloromethane and methanolic extracts exhibited significant phytotoxicity against Lemna minor having Paraquat as standard drug and incubation condition (28±1ºC).


Results: None of extracts presented any significant cytotoxic activity having Imipenum and Etoposide as standard drug respectively. Both extract had non-significant antifungal activity but it has been noted that methanol extract showed 30% inhibition with linear growth at 70 mm, when compared with control; only against Microsporum canisRanunculus muricatus showed significant phytotoxicity.


Conclusion: The phytotoxicty assay is a valuable major screen for weedicide investigation. Additionally, modern studies are currently carried out to identify the allelopathic constituents by isolation, purification and structure elucidation to find out as effective herbicidal.


         2.JPG


google_s_2.JPG       PubMed16.jpg


Peer Review History:


Article received on- 9 September    Revised on- 16 September   Accepted on- 25 September, Available online 15 November 2016


Academic Editor: Dr. Ali Abdullah Al-yahawiorcid22.jpg, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com


UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.


Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Dr. Awofisayo, O Abosedeorcid22.jpg, University of Uyo, Nigeria, shalomgirl08@yahoo.com


Prof. Dr. Ali Gamal Ahmed Al-kaforcid22.jpg, Sana'a university, Yemen, alialkaf21@gmail.com


This article has been cited by:


Zhang, Wenying. “Development of a Graphene Based Electrochemical Sensor for the Determination of 9-hydroxyrisperidone in Human Blood Plasma.” International Journal of Electrochemical Science (2018): 2617-2626. Pubmed

Keywords: Ranunculus muricatus, biological screening, phytotoxicity, cytotoxicity

Downloads

Download data is not yet available.
Comments

Statistics
281 Views | 500 Downloads
How to Cite
Aslam, M., R. Rehman, B. Choudhary, A. Ijaz, M. Uzair, and M. Ahmad. “ANTIFUNGAL, CYTOTOXIC AND PHYTOTOXICITY OF AERIAL PART OF RANUNCULUS MURICATUS”. Universal Journal of Pharmaceutical Research, Vol. 1, no. 1, Sept. 2016, doi:https://doi.org/10.22270/ujpr.v1i1.R2.
Section
Research Articles