EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA

  • Arun Kumar Singh Devsthali Vidyapeeth Collge of Pharmacy, Rudrapur, Uttarakhand , India https://orcid.org/0000-0001-7657-0964
  • Anita Singh Department Of Pharmaceutical Sciences Bhimtal Campus,Kumaun University ,Nainital Uttarakhand, India. https://orcid.org/0000-0001-5569-8184
  • N.V Satheesh Madhv DIT University, Faculty of Pharmacy, Mussoorie Diversion Road, Dehradun, Uttarakhand, India.

Abstract

The objective of present investigation was to isolate an effective novel mucoadhesive biomaterial from the pulp of Achras Zapotilla, belonging to Sapotaceae family. In the recent years the research in the biomaterial isolation and their use as pharmaceutical excipient become a core area for formulation scientist to develop safe and effective drug delivery system. The biomaterial was isolated by simplified economical method and was subjected to phytochemical, physicochemical, micromeritic as well as spectral analyses like IR, 1HNMR, DSC, SEM and Elemental analysis. The mucoadhesive property of the biomaterial was assessed by shear stress method, falling sphere method and rotating cylinder method using nasal mucosa as substrates. The results were compared with HPMC and sodium CMC as a standard. The formation of hydrogen bond by natural mucoadhesive agent with mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups. The research study revealed that the biomaterial obtained from fruit pulp of Acarus zapotila exhibited a promising potent natural mucoadhesive property and may be used to develop mucoadhesive transmucosal drug delivery systems.


Peer Review History:


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Received file


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Average Peer review marks at initial stage: 4.5/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Name: Areen Alshweiat


Affiliation: University of Szeged, Hungary


E-mail: areen.alshweiat@hu.edu.jo


 


Name: Dr. Emmanuel O. Olorunsola


Affiliation: Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria


E-mail: olorunsolaeo@yahoo.com


Comments of reviewer(s):


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Keywords: Nasal Mucosa, mucoadhesive property, shear stress testing, achras zapotilla, x-ray diffraction spectroscopy, thermal analysis
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How to Cite
Singh, A., A. Singh, and N. Madhv. “EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 6, Nov. 2017, doi:https://doi.org/10.22270/ujpr.v2i6.R6.
Section
Research Articles