THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN
Objectives: Celiac disease’s potentially destructive effect on reproductive health is among the most vital matters associated with progress awareness. Men and women with unexplained infertility, women with recurrent abortions, intrauterine growth retardation, low birth weight babies and menstrual disorders are not often screened for celiac disease (CD) despite scientific studies that point to a correlation. The aims of the present study were to examine the evidence of the correlation between CD and infertility by measuring sex hormones in CD comparing healthy controls (HC).
Methods: The study was carried out in Autoimmune Unit, AL-Thowra Hospital Sana’a city, Yemen. The study included 32 CD patients, and 32 HC. Blood samples were collected then examined for sex hormones in both.
Results: There was highly significant low down level of the mean±SD of sex hormones among male and female CD than HC: for male CD FSH=1.96±1.4 IU/ml vs 3.3±1.27 IU/ml of HC, LH=3.9±3.3 IU/ml vs 6.5±2.03 IU/ml of HC; and the testosterone=1.03±0.76 IU/ml, vs 3.8±1.4 IU/ml of HC. For CD females the mean ± SD of FSH, for CD females was 4.37±2.46 IU/ml vs 4.92±2.35 IU/ml of HC, Estradiol (40.7±30.8 IU/ml vs 7.1±76.66 IU/ml of HC), and Progestrone (1.2±1.15 IU/ml, vs 6.4±4.38 IU/ml of HC).
Conclusion: In conclusion, there was significant association between CD and infertility among Yemeni CD patients in which it indicated by low sex hormones in CD patients.
Peer Review History:
Received 6 December 2017; Revised 3 January; Accepted 8 January, Available online 15 January 2018
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Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.5/10
Name: Dr. Sameh Abdelmoneem Mohammed Ali
Affiliation: Faculty of Pharmacy, Beni-Suef University, Egypt
Name: Dr. Sunita Singh
Affiliation: Baylor College of Medicine, Houston, Texas, USA
Comments of reviewer(s):