THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN

  • Al-Anesi Mohsen Department of biochemistry and molecular biology, Guangxi Medical University, China
  • Qiping Hu Department of biochemistry and molecular biology, Guangxi Medical University, China https://orcid.org/0000-0003-4654-5076
  • Ekram Al-Eryani Department of biochemistry, Faculty of Medicine and Heath Sciences, Sana’a University, Yemen
  • Mansour Al-Amrani Department of biochemistry, Faculty of Medicine and Heath Sciences, Sana’a University, Yemen
  • Hassan Al-Shamahy Faculty of Medicine and Heath Sciences, Sana’a University, Yemen https://orcid.org/0000-0001-6958-7012

Abstract

Celiac disease’s potentially destructive effect on reproductive health is among the most vital matters associated with progress awareness. Men and women with unexplained infertility, women with recurrent abortions, intrauterine growth retardation, low birth weight babies and menstrual disorders are not often screened for celiac disease (CD) despite scientific studies that point to a correlation. The aims of the present study were to examine the evidence of the correlation between CD and infertility by measuring sex hormones in CD comparing healthy controls (HC).The study was carried out in Autoimmune Unit, AL-Thowra Hospital Sana’a city, Yemen. The study included 32 CD patients, and 32 HC. Blood samples were collected then examined for sex hormones in both. There was highly significant low down level of the mean ± SD of sex hormones among male and female CD than HC: for male CD  FSH=1.96±1.4 IU/ml vs 3.3±1.27 IU/ml of HC, LH=3.9±3.3 IU/ml vs 6.5±2.03 IU/ml of HC; and the testosterone=1.03±0.76 IU/ml, vs 3.8±1.4 IU/ml of HC. For CD females the mean ± SD of FSH, for CD females was 4.37±2.46 IU/ml vs 4.92±2.35 IU/ml of HC,  Estradiol (40.7±30.8 IU/ml vs 7.1±76.66 IU/ml of HC), and Progestrone (1.2±1.15 IU/ml, vs 6.4±4.38 IU/ml of HC). In conclusion, there was significant association between CD and infertility among Yemeni CD patients in which it indicated by low sex hormones in CD patients.


Peer Review History:


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Received file


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Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Dr. Sameh Abdelmoneem Mohammed Ali


Affiliation: Faculty of Pharmacy, Beni-Suef University, Egypt


E-mail: same7_pharma18@yahoo.com


 


Name: Dr. Sunita Singh


Affiliation: Baylor College of Medicine, Houston, Texas, USA


E-mail: sunita.nccs@gmail.com


Comments of reviewer(s):


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Keywords: Celiac disease, infertility, sex hormones, Sana’a, Yemen
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How to Cite
Mohsen, A.-A., Q. Hu, E. Al-Eryani, M. Al-Amrani, and H. Al-Shamahy. “THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 6, Nov. 2017, doi:https://doi.org/10.22270/ujpr.v2i6.R5.
Section
Research Articles